Qing-Xiang Amy SANG, Ph.D.
Associate Professor
Ph.D. Georgetown University Medical Center, Washington D.C., 1990


Biochemistry Division
Department of Chemistry and Biochemistry
Florida State University
Tallahassee, FL 32306-4390

E-mail: qxsang@chem.fsu.edu
PHONE: (850) 644-8683
FAX: (850) 644-8281
DLC 203


Research - Selected Publications - Group members - Conference Lectures & Posters - Invited Lectures & Seminars - Honors, Awards and Other information



Left to Right (front): Daniel J. Trueblood, Suzan M. Semaan, Prof. Qing-Xiang Amy Sang, Megan E. Muroski, Zahraa I. Khamis, Holly R. Monroe

Left to Right (back): Chi Ben, Mark Druen Roycik, Dr. Ziad J. Sahab, Robert G. Newcomer, Qiang Cao, Seakwoo Lee

 


Protein chemistry, enzymology, biochemistry, and molecular biology of new matrix metalloproteinases (MMPs, matrixins), tissue inhibitors of metalloproteinases (TIMPs), and membrane proteinases/receptors, disintegrin and metalloproteinase-like proteins (ADAMs, adamalysins), including discovering and characterizing novel human endometase/matrilysin-2/matrix metalloproteinase-26 (MMP-26) and human adamalysin-19/disintegrin and metalloproteinase-19/ADAM19, cDNA cloning, expression, isolation, purification, characterization, sequencing, and chemical modification of proteins.

Biochemical basis and cellular and molecular mechanisms of human breast and prostate cancer cell progression, invasion, and metastasis; role of MMPs and natural and synthetic inhibitors of MMPs in cancer cell invasion and in angiogenesis (new blood vessel formation); inhibition of cancer cell invasion and metastasis and inhibition of angiogenesis by metalloproteinase inhibitors.

 Biochemical and pathological activation mechanisms of human metalloproteinases, such as the novel endometase and adamalysin-19. Substrate specificities of MMPs and inhibition mechanisms of MMPs by TIMPs and synthetic inhibitors. Structure-function relationships of metalloproteinases and their inhibitors, metalloprotease/disintegrin proteins, and extracellular matrix proteins.  Computational sequence analysis, homology modeling, and secondary and tertiary structure prediction of MMPs, TIMPs, and other proteins.  Bioinformatics, functional genomics, and proteomics.


 Role of focal basal cell disruption in human prostate and focal myoepithelial cell disruption in human breast invasion. “Mutated cancer stem cell hypothesis”. The plasticity of human cancer cells and stromal cells, epigenetic changes of cancer cells, microenvironmental factors, tumor-stromal interactions in cancer invasion, angiogenesis, progression, and metastasis.

  Bioanalytical chemistry, proteomics, and biomarker identification and characterization for invasive human cancers and for cardiovascular diseases and stroke. Molecular mechanisms of disease prevention, diagnosis, and treatment.

  Molecular mechanisms of atherosclerosis and restenosis, role of metalloproteinases in cardiovascular diseases.


Back to the top

1.  Q.-X. Sang, M. Dym, and S.W. Byers (1990) Secreted metalloproteinases in testicular cells in culture, Biol.Reprod. 43, 946-955.

2. Q.-X. Sang, W.G. Stetler-Stevenson, L.A. Liotta, and S.W. Byers (1990) Identification of type IV collagenase in rat testicular cell culture: influence of peritubular-Sertoli cell interactions, Biol.Reprod. 43, 956-964.

3. Q.-X. Sang (1990) Testicular metalloproteinases; regulation by hormones and Sertoli-peritubular cell interactions in vitro, Ph.D. Dissertation, Georgetown University, Washington D.C.

4. Q.-X. Sang, D. Grant, E.W. Thompson, W.G. Stetler-Stevenson, and S.W. Byers (1991) Soluble laminin and arginine-glycine-aspartic acid containing peptides differentially regulate type IV collagenase messenger RNA, activation and localization in testicular cell culture, Biol. Reprod., 45, 387-394.

5. Q.-X. Sang, M. Dym, and S.W. Byers (1992) Proteases in seminiferous epithelium remodeling, Matrix, supplement, 1, 404-405.

6. S. Netzel-Arnett, Q.-X. Sang, W.G.I. Moore, M. Navre, H. Birkedal-Hansen, and H.E. Van Wart (1993) Comparative sequence specificities of human 72 and 92 kDa gelatinases (type IV collagenases) and PUMP (matrilysin), Biochemistry, 32, 6427-6432.

7. Q.-X. Sang, H. Birkedal-Hansen, and H.E. Van Wart (1995) Proteolytic and non-proteolytic activation of human neutrophil progelatinase, Biochim. Biophy. Acta, 1251, 99-108.

8. Q.A. Sang (1995) Specific proteolysis of ceruloplasmin by leukocyte elastase, Biochem. Mol. Biol. Int. 37, 573-581.

9. Q.A. Sang and D.A. Douglas (1996) Computational sequence analysis of matrix metalloproteinases, J. Protein Chem. 15, 137-160.

10. Q.A. Sang, M.K. Bodden, and L.J. Windsor (1996) Activation of human progelatinase A by collagenase and matrilysin; activation of procollagenase by matrilysin, J. Protein Chem. 15, 243-253.

11. M.A. Stolow, D.D. Bauzon, J. Li, T. Sedgwick, V.C.-T. Liang, Q.A. Sang, and Y.-B. Shi (1996) Identification and characterization of a novel collagenase in Xenopus laevis: Possible roles during frog development, Mol. Biol. Cell, 7, 1471-1483.

12. H.E. Zhau, S.-M. Chang, B.-Q. Chen, Y. Wang, H. Zhang, C. Kao, Q.A. Sang, S.J. Pathaks, and L.W.K. Chung (1996) Androgen-repressed phenotype in human prostate cancer, Proc. Natl. Acad. Sci. USA, 93, 15152-15157.

13. D.A. Douglas, Y.E. Shi, and Q.A. Sang (1997) Computational sequence analysis of the tissue inhibitor of metalloproteinase family, Minireview, J. Protein Chem. 16, 237-255.

14. C.-Y. Lin, J.-K. Wang, J. Torri, L. Dou, Q.A. Sang, and R.B. Dickson (1997) Characterization of a novel, membrane-bound 80-kDa matrix-degrading protease from human breast cancer cells: monoclonal antibody production, isolation, and localization, J. Biol. Chem. 272, 9147-9152.

15. Y. E. Liu, M. Wang, J. Greene, J. Su, S. Ullrich, H. Li, S. Sheng, P. Alexander, Q.A. Sang, and Y.E. Shi (1997) Preparation and characterization of recombinant tissue inhibitor of metalloproteinase 4 (TIMP-4), J. Biol. Chem. 272, 20479-20483

16. B.C. Patterson and Q.A. Sang (1997) Angiostatin converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9), J. Biol. Chem., 272, 28823-28825

17. H. Li, D.D. Bauzon, X. Xu, H. Tschesche, J. Cao, and Q.A. Sang (1998) Immunological characterization of cell surface and soluble forms of membrane-type 1 matrix metalloproteinase in human breast cancer cells and fibroblasts, Molecular Carcinogenesis 22, 84-94

18. Y.-B. Shi and Q.A. Sang (1998) 392. Collagenase 4. In Handbook of Proteolytic Enzymes. Editors: A.J. Barrett, N.D. Rawlings, and J.F. Woessner. pp. 1170-1172, Academic Press, Orlando, Florida.

19. Q.X. Sang (1998) Complex role of matrix metalloproteinases in angiogenesis. Minireview. Cell Res. 8, 171-177

20. C.M. Dollery, J.R. McEwan, M. Wang, Q.A. Sang, Y.E. Liu, Y. Eric Shi (1999) TIMP-4 is regulated by vascular injury in rats. Circulation Research 84, 498-504

21. G. Xiao, Y.E. Liu, R. Gentz, Q.A. Sang, J. Ni, I.D. Goldberg, Y.E. Shi (1999) Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells. Proc. Natl. Acad. Sci. USA. 96, 3700-3705

22. A.L. Stone, M. Kroeger, and Q.X. Sang (1999) Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase containing proteins. Review. J. Protein Chem. 18, 447-465.

23. Q.A. Sang, M.A. Schwartz, H. Li, L.W.K. Chung, and H.E. Zhau (1999) Targeting matrix metalloproteinases in human prostate cancer. Ann. N.Y. Acad. Sci. 878, 538-540.

24. C.-Y. Lin, J. Anders, M. Johnson, Q.A. Sang, and R.B. Dickson (1999) Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity. J. Biol. Chem. 274, 18231-18236.

25. S.C. Mueller, G. Ghersi, S.K. Akiyama, Q.X. Sang, L. Howard, M. Pineiro-Sanchez, H. Nakahara, Y. Yeh, and W.-T. Chen (1999) A novel protease-docking function of integrin at invadopodia. J. Biol. Chem. 274, 24947-24952.

26. C.M. Dollery, J.R. McEwan, M. Wang, Q.A. Sang, Y.E. Liu, and Y.E. Shi (1999) TIMP-4 is regulated by vascular injury in rats. Ann. N.Y. Acad. Sci. 878, 740-741.

27. M.-C. Jia, M. A. Schwartz, and Q.A. Sang (2000) Suppression of human microvascular endothelial cell invasion and morphogenesis with synthetic matrixin inhibitors, Targeting angiogenesis with MMP inhibitors. Adv. Exp. Med. Biol. 476, 181-194.

28. S. Hernandez-Barrantes, M. Toth, M.M. Bernardo, M. Yurkova, D.C. Gervasi, Y. Raz, Q.A. Sang, R. Fridman (2000) Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation. J. Biol. Chem. 275, 12080-12089.

29. H.I. Park, J. Ni, F.E. Gerkema, L. Ding, V.E. Belozerov, and Q.-X. Sang (2000) Identification and Characterization of Human Endometase (Matrix Metalloproteinase-26) from Endometrial Tumor. J. Biol. Chem. 275, 20540-20544.

30. Q.-X. Sang, M.-C. Jia, M.A. Schwartz, M.C. Jaye, H.K. Kleinman, M.A. Ghaffari, and Y.-L. Luo (2000) New thiol and sulfodiimine metalloproteinase inhibitors and their effect on human microvascular endothelial cell growth. Biochem. Biophys. Res. Commun. 274,780-786.

31. P. Wei, Y.G. Zhao, L. Zhuang, S. Ruben, and Q.-X. Sang (2001) Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19 (meltrin beta). Biochem. Biophys. Res. Commun. 280, 744-755.

32. Hurst, D. R., Li, H., Xu, X., Badisa, V. L., Shi, Y. E., and Sang, Q.-X. (2001). Development and characterization of a new polyclonal antibody specifically against tissue inhibitor of metalloproteinases 4 (TIMP-4) in human breast cancer. Biochem. Biophys. Res. Commun. 281,166-171.

33. S. Hernandez-Barrantes, Y. Shimura, P.D. Soloway, Q.A. Sang, and R. Fridman (2001) Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP. Biochem. Biophys. Res. Commun. 281, 126-130.

34. Y. Jiang, M. Wang, M.Y. Celiker, Q.-X. Sang, Y.E. Liu, I.D. Goldberg, and Y.E. Shi (2001). Stimulation of mammary tumorigenesis by systemic tissue inhibitors of matrix metalloproteinase 4 gene delivery. Cancer Res. 61, 2365-2370.

35. Y.-G. Zhao, P. Wei, and Q.-X. Sang (2001) Inhibitory Antibodies against Endopeptidase Activity of Human Adamalysin 19. Biochem. Biophys. Res. Commun. 289, 288-294.

36.  J. Zhang, Y.-J. Cao, Y.-G. Zhao, Q.-X. Sang, and E.-K. Duan (2002) Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3. Mol. Human Reprod. 8, 659-666.

37. P. Wei, Y.-G. Zhao, L. Zhuang, D.R. Hurst, S. Ruben, and Q.-X. Sang (2002) Protein Engineering and Properties of Human Metalloproteinase and Thrombospondin 1.  Biochem. Biophys. Res. Commun.  293, 478-488.

38. T.-B. Kang, Y.-G. Zhao, D. Pei, J.F. Sucic, and Q.-X. Sang (2002) Intracellular Activation of Human Adamalysin 19/Disintegrin and Metalloproteinase 19 by Furin Occurs via One of the Two Consecutive Recognition Sites.  J. Biol. Chem. 277, 25583-25591.

39. H.I. Park, B.E. Turk, F.E. Gerkema, L.C. Cantley, and Q.-X. Sang (2002) Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.  J. Biol. Chem.  277, 35168-35175.

40. Li, Q., Wang, H., Zhao, Y., Lin, H., Sang, Q.A., Zhu, C. (2002) Identification and specific expression of matrix metalloproteinase-26 in rhesus monkey endometrium during early pregnancy. Mol. Hum. Reprod. 8, 934-940.

41. T. Kang, H. I., Park, Y. Suh, Y.-G. Zhao, H. Tschesche, and Q.-X. Sang (2002) Autolytic Processing at Glu(586)-Ser(587) within the Cysteine-rich Domain of Human Adamalysin 19/Disintegrin-metalloproteinase 19 is Necessary for its Proteolytic Activity.  J. Biol. Chem. 277, 48514-48522.

 

42.              Y.-G. Zhao, A. Xiao, R.G. Newcomer, H.I. Park, T. Kang, L.W.K. Chung, M.G. Swanson, H. E. Zhau, J. Kurhanewicz,  and Q.-X. Sang (2003) Activation of Pro-Gelatinase B by Endometase/Matrilysin-2 Promotes Invasion of Human Prostate Cancer Cells.  J. Biol. Chem. 278, 15056-15064.

 

43. J. Zhang, Y.-J. Cao, Y.-G. Zhao, Q.-X. Sang, and E.-K. Duan (2003) Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo. Mol. Hum. Reprod. 9, 143-149.

 

44.              X. Liao, J.B. Thrasher, J. Pelling, J. Holzbeierlein, Q.-X. Sang, and B. Li (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer.  Endocrinology. 144, 1656-1663.

 

45.              R. Tunuguntla, D. Ripley, Q.-X. A. Sang, and N. Chegini (2003) Expression of Matrix Metalloproteinase-26 and Tissue Inhibitors of Metalloproteinases TIMP-3 and –4 in Benign Endometrium and Endometrial Cancer. Gynecologic Oncology.  89, 453-459.

 

46.              H.I. Park, Y. Jin, D.R. Hurst, C.A. Monroe, S. Lee, M.A. Schwartz, and Q.-X. Sang (2003) The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J. Biol. Chem., 278:51646-51653.

 

47.              D. R. Hurst, M.A. Schwartz, M.A. Ghaffari, Y. Jin, H. Tschesche, G.B. Fields, and Q.-X. Sang (2004)  Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities. Biochem. J. 377, 775-779.

 

48.              Y.-G. Zhao, A.-Z. Xiao, H.I. Park, R.G. Newcomer, M. Yan, Y.-G. Man, S.C. Heffelfinger, and Q.-X. Sang (2004) Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4:  a putative role in the initiation of breast cancer invasion.  Cancer Res. 64, 590-598.

 

49.              T. Kang, H. Tschesche, and Q.-X. Sang (2004) Evidence for Disulfide Involvement in the Regulation of Intramolecular Autolytic Processing by Human Adamalysin19/ADAM19. Exp. Cell Res. 298, 285-295.

 

50.              Y.-G. Man and Q.-X. Sang (2004) The Significance of Focal Myoepithelial Cell Layer Disruptions in Human Breast Tumor Invasion: a Paradigm Shift from the “Protease-centered” Hypothesis. Exp. Cell Res. 301, 103-118.

 

51.              Q.X. Sang and Y.-B. Shi (2004) Collagenase 4.  In Handbook of Proteolytic Enzymes. Chapter 128. 2nd edition.  Editors:  A.J. Barrett, N.D. Rawlings, and J.F. Woessner.  Elsevier Academic Press, London, San Diego. pp. 494-497.

 

52.               Q.X. Sang (2004) Matrilysin-2.  In Handbook of Proteolytic Enzymes. Chapter 135.  2nd edition.  Editors:  A.J. Barrett, N.D. Rawlings, and J.F. Woessner.  Elsevier Academic Press, London, San Diego. pp. 538-540.

 

53.              T. Kang, R.G. Newcomer, Y.-G. Zhao, and Q.-X. Sang (2005) Chapter 9: ADAM19: Domain structure, regulation, processing and functions. “The ADAMs Family of Proteases”. In the Proteases in Biology and Disease series. Vol. 4. Editors: N.M. Hooper and U. Lendeckel.  Springer, The Netherlands, pp.199-221.

 

54.              W. Qiu, L. Zhao, S.-X. Bai, Q.-X. Sang, Y.-L. Wang (2005) Expression of matrix metalloproteinase-26 in human normal placental cytotrophoblast cells as well as its regulation by activin A. Prog. Biochem. Biophys. 32, 25-30.

 

55.              W. Qiu, S.-X. Bai, M.-R. Zhao, X.-Q. Wu, Y.-G. Zhao, Q.-X. Sang, Y.-L. Wang (2005) Spatio-temporal expression of matrix metalloproteinase-26 in human placental trophoblasts and fetal red cells during normal placentation. Biol. Reprod. 72, 954-959 [Epub ahead of print, 2004 Dec 15].

 

56.              Y.-G. Man, T. Shen, Y.-G. Zhao, and Q.-X. Sang (2005) Focal prostate basal cell layer disruptions and leukocyte infiltration are correlated events: A potential mechanism for basal cell layer disruptions and tumor invasion. Cancer Detect. Prev. 29, 161-169.

 

57.              H.-X. Wang, Y.-G. Zhao, H.M. Wang, Q. Yang, H.-Y. Lin, Q.-X. Sang, C. Zhu (2005) Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy.  Mol Hum Reprod. 11, 429-435. Epub 2005 May 18.

 

58.              D.R. Hurst, M.A. Schwartz,Y. Jin, M.A. Ghaffari, P. Kozarekar, J. Cao, Q.-X. Sang (2005) Inhibition of enzyme activity and cell-mediated substrate cleavage of membrane type 1-matrix metalloproteinase by newly developed mercaptosulfide inhibitors. Biochem. J. 392, 527-536. Epub 2005 Jul 19.

 

59.              Y.-G. Man, T. Shen, J. Weisz, P.E. Berg, A.M. Schwartz, J.L. Mulshine, Q.-X. Sang, and H.E. Nieburgs (2005) A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasion. Cancer Detect. Prev. 29, 323-331. Epub 2005 Aug. 22.

 

60.              Z.J. Sahab, Y. Suh, and Q.-X. Sang (2005) Isoelectric point-based prefractionation of proteins from crude biological samples prior to two-dimensional gel electrophoresis. J. Proteome Res. 4, 2266-2272. Epub 2005 Nov. 18.

 

61.              Q.-X. Sang, Y. Jin, R.G. Newcomer, S.C. Monroe, X. Fang, D.R. Hurst, S. Lee, Q. Cao, and M.A. Schwartz (2006) Matrix Metalloproteinase Inhibitors as Prospective Agents for the Prevention and Treatment of Cardiovascular and Neoplastic Diseases. Current Topics in Medicinal Chemistry. 6, 289-316. Invited review.

 

62.              Q. Yang, H.X. Wang, Y.G. Zhao, H.Y. Lin, H. Zhang, H.M. Wang, Q.X. Sang, C. Zhu. (2006) Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Life Sci. 78, 2804-2811. 2005 Dec 20; [Epub ahead of print].

 

63.              S. Bu, C. Cao, Y. Yang, C. Miao, Z. Hu, Y. Cao, Q. A. Sang, and E. Duan (2006) Localization and temporal regulation of tissue inhibitor of metalloproteinases-4 in mouse ovary. Reproduction. 131, 1099-1107.

 

64.              D. Wildeboer, S. Naus, Q.-X. Sang, J.W. Bartsch, and A. Pagenstecher (2006) Metalloproteinase-disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness. J. Neuropathol. Exp. Neurol. 65, 516-527.

 

65.              S.-M. Bu, Y.-J. Yang, C.-L. Miao, H.-J. Li, R.G. Newcomer, Q.-X. Sang, E.-K. Duan (2006) Developmental and hormonal regulation of meltrin beta (ADAM19) expression in mouse testes during embryonic and postnatal life. . Life Sci. 79, 2112-2118.

 

66.              S. Lee, K. K. Desai, K.A. Iczkowski, R.G. Newcomer, K.J. Wu, Y.-G. Zhao, W.W. Tan, M.D. Roycik, and Q.-X. Sang (2006) Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor. Cell Res. 16, 750-758.

 

67.              Z.J. Sahab, S.M. Semaan, and Q.-X. Sang (2007) Methodology and Applications of Disease Biomarker Identification in Human Serum. Invited Review. Biomarker Insights. 2, 21-43.

 

68.              S. Lee, H.I. Park, and Q.-X. Sang (2007) Calcium Regulates Tertiary Structure and Enzymatic Activity of Human Endometase/Matrilysin-2 and its Role in Promoting Human Breast Cancer Cell Invasion.  Biochem. J. 403, 31-42.

 

69.              Z.J. Sahab, K. Iczkowski, and Q.-X. Sang (2007) Anion Exchange Fractionation of Serum Proteins versus Albumin Elimination.  Anal. Biochem. 368, 24-32.

 

70.              M.E. Muroski, M.D. Roycik, R.G. Newcomer, P.E. Van den Steen, G. Opdenakker, H.R. Monroe, Z.J. Sahab, and Q.-X. Sang (2007) Matrix Metalloproteinase-9/Gelatinase B is a Putative Therapeutic Target of Chronic Obstructive Pulmonary Disease and Multiple Sclerosis. Current Pharmaceutical Biotechnology, Invited Review. In press.

 

71.              J. Hu, P.E. Van den Steen, Q.-X. Sang , and G. Opdenakker (2007) Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nature Reviews Drug Discovery. 6, 480-498. Invited review.

 

 


Back to the top


Graduate, Undergraduate Students, Postdoctoral and other Research Assistants/Associates Trained in Dr. Sang's Lab


Graduate Students:

Former: Delbert D. Bauzon, Paul H. Schmid, Brian C. Patterson, Anne L. Stone, Shawn A. Clark, Vladimir E. Belozerov, Andrew A. Korostelev, Laura A. Mertz, Cheri Bunder, Bradley D. Prater, Sonia Hernandez-Barrantes, Fuli Yu, Georgia A. Wilkie, Jocelyn Dudley, Elena Filenova, Faqing Yuan, Mitesh Jivan, Douglas R. Hurst (graduated with a Ph.D. degree in Biochemistry in Dec. 2003), Ziad Sahab (graduated with a Ph.D. degree in Bioanalytical Chemistry in Dec. 2005), Yewseok Suh (graduated with a Ph.D. degree in Biochemistry in Aug. 2006),

Current:, Seakwoo Lee, Robert G. Newcomer, Qiang Cao, Mark Dru Roycik, Daniel Trueblood, Suzan Marie Semaan, Chi Ben and Zahraa I. Khamis.


Undergraduate Students:

Former: Annette Vaughan, Damon A. Douglas, Rachel K. Stilwell, Scott A. Gass, Michael B. Dillhyon, Ian Davis, Mayra Martin, James Mike Magill, Edwin Alex Melendez, Nneka Lotea Ifejika, William Richard Mansfield, III, Karyn M. Usher, Charles Quincy Adams, Stacie Kemp Wilensky, Andy Rodriguez, Ferry E. Gerkema, Marjoleine H. Bleijenberg, Sara C. Monroe, Cyrus A. Monroe, Joseph Lichter, Katie Berry, Shelbourn (Shelby) Kent, Ehsan (Sonny) Achtchi, Margie Coryn, Melanie Overland, Colesha Jackson,  Kevin K. Desai, Jennifer Walker, and Amjad Asker.

Current:  Megan E. Muroski and Holly Monroe.


Postdoctoral and other Research Assistants /Associates:

Former: Hui Li, ShiDeng Bao, Dr. XinYun Xu, Dr. Wan-Qian Zhao, Dr. Meng-Chun Jia, Veera Lakshmi Devi Badisa, Dr. Michaela Kroeger, J. Mike Magill, Dr. Laurence D. Covassin, Mr. Asad Ullah, Dr. Hyun I. Park, Dr. Tiebang Kang, Dr. Aizhen Xiao, and Dr. Yunge Zhao

Current:  Dr. Ziad J. Sahab, Dr. Yewseok Suh


Back to the top


Lectures and posters presented in conferences

1. Q.-X. Sang, M. Dym, and S.W. Byers (1988) Sertoli cell plasma membrane associated and secreted plasminogen-independent proteases (PIPs), J.Cell Biol. 107, 616a

2. Q.-X.Sang, M. Dym, and S.W. Byers (1988) Characterization of Sertoli cell plasma membrane associated and secreted plasminogen-independent proteases, in Regulation of Testicular Function: Signaling Molecules and Cell-Cell Communications, 10th Annual Testis Workshop, 71a

3. S.W. Byers, Q.-X. Sang, H.N. Dai, J. Beaudry, and B. Hoxter (1989) The Sertoli cell plasma membrane and plasminogen-independent proteases in seminiferous epithelium remodeling, in Serono Symposia Review, Supplement I, IV International Congress of Andrology, 21a

4. S.W. Byers, Q.-X. Sang, H.N. Dai, J. Beaudry, and B. Hoxter (1989) Isolation and characterization of Sertoli cell plasma membrane and junctional specializations, Anatomical Record 223, 20a

5. Q.-X. Sang, and S.W. Byers (1989) Matrix metalloproteinases in rat testicular cell culture, J.Cell Biol. 109, 135a

6. Q.-X. Sang, D. Grant, E.W. Thompson, W.G. Stetler-Stevenson, and S.W. Byers (1990) Soluble laminin and RGD-containing peptides differentially regulate type IV collagenase mRNA, activation and localization in testicular cell culture, J.Cell Biol. 111, 15a

7. Q.-X. Sang, H. Birkedal-Hansen, and H.E. Van Wart, (1993) Activation of human neutrophil progelatinase/type IV collagenase by matrilysin and fibroblast collagenase, Molecular Biology of the Cell (suppl.), 4, 287a

8. Q.-X. Sang, H. Birkedal-Hansen, and H.E. Van Wart (1994) Activation of human progelatinase A and B (type IV collagenases) by matrilysin and fibroblast collagenase, Molecular Genetics of Tumor Progression and Metastasis -- A Special Conference of the American Association for Cancer Research, page B-26

9. Q.-X. Sang, H. Birkedal-Hansen, and H.E. Van Wart (1995) Regulation of human type IV collagenase activity. The American Cancer Society, Florida Division, Inc., 18th Annual Seminar of Florida Cancer Researchers. 3/25/1995, Orlando, Florida.

10. Q.-X. Sang and J.M. Caffrey (1995) Hydrolysis of porcine ceruloplasmin by human leukocyte elastase. Cambridge Healthtech Institute's Angiogenesis Antagonists -- New Cancer Strategies. Washington D.C.

11. Q.-X. Sang, H. Birkedal-Hansen, and H.E. Van Wart (1995) Proteolytic activation of progelatinases A and B. Gordon Research Conference on Matrix Metalloproteinase, Proctor Academy, Andover, NH.

12. Q.A. Sang and H. Li (1996) Regulation of breast cancer type IV collagenase activity by laminin and laminin-derived peptides. Proteases and Protease Inhibitors in Cancer. A Special Conference of American Association for Cancer Research, page A-31. Panama City Beach, Florida.

13. D.A. Douglas and Q.A. Sang (1996) Computational sequence analysis of the matrix metalloproteinase family. The American Cancer Society, Florida Division, Inc., 19th Annual Seminar of Florida Cancer Researchers. Orlando, Florida.

14. D.D. Bauzon, M.A. Stolow, Y.-B. Shi, and Q.A. Sang (1996) Identification and characterization of a novel collagenase in Xenopus laevis. The American Cancer Society, Florida Division, Inc., 19th Annual Seminar of Florida Cancer Researchers. Orlando, Florida.

15. Hui Li and Q.A. Sang (1996) Regulation of breast cancer type IV collagenase activity by laminin and laminin-derived peptides. The American Cancer Society, Florida Division, Inc., 19th Annual Seminar of Florida Cancer Researchers. Orlando, Florida.

16. Q.A. Sang, H. Li, and D.D. Bauzon (1996) Activation of breast cancer type IV collagenases. Gordon Research Conference on Basement Membrane. New England College, Henniker, NH.

17. Q.A. Sang and D.A. Douglas (1996) Computational sequence analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases, Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors. Colby-Sawyer, New Hampshire.

18. D.D. Bauzon, J. Li, M.A. Stolow, Y.-B. Shi, and Q.A. Sang (1996) Biochemical characterization of a novel collagenase from Xenopus laevis. Mol. Biol. Cell 7, 59a.

19. H. Li, D.D. Bauzon, and Q.A. Sang (1997) Cell surface metalloproteinase in breast cancer cells and fibroblasts. Fibronectins, Integrins and Related Molecules, Gordon Research Conference. Ventura, CA.

20. H. Li, D.D. Bauzon, and Q.A. Sang (1997) Breast cancer membrane type-1 matrix metalloproteinases. Poster #34, American Chemical Society, Florida Sections, 1997 Annual Meeting. Orlando, Florida.

21. B. C. Patterson and Q.A. Sang (1997) Potential angiostatin converting enzyme activities of human matrilysin and gelatinase B. American Chemical Society, Florida Sections. Orlando, Florida.

22. D. E. Bauzon, J.M. Magill, L.J. Windsor, J.W. Li, Y.-B. Shi, and Q.A. Sang (1997) Hydrolysis of type I, II, and III collagens by frog collagenase-4. American Chemical Society, Florida Sections. Orlando, Florida.

23. Q.X.A. Sang, Y.E. Shi, and D.A. Douglas (1997) Computational sequence analysis of matrix metalloproteinases and their tissue inhibitors. Cambridge Healthtech Institute's Beyond the Human Genome Project, from Genes to Proteins and Bioinformatics. June 9-12, 1997. San Francisco, California.

24. D.D. Bauzon, L.J. Windsor, J. Li, Y.-B. Shi, and Q.A. Sang, Substrate specificities of frog collagenase-4 (MMP-18). Gordon Research Conference on Matrix Metalloproteinase, Proctor Academy, Andover, NH. July 13-18, 1997.

25. H.Li, D.D. Bauzon, and Q.A. Sang, Novel human breast cancer cell surface metalloproteinases. Gordon Research Conference on Cancer, Salve Regina, RI. August 3-8, 1997.

26. B.C. Patterson and Q.A. Sang, Human matrilysin and gelatinase B, candidates for angiostatin converting enzymes. Gordon Research Conference on Angiogenesis and Microcirculation, Salve Regina, RI. August 17-22, 1997.

27. S.C. Mueller, G. Ghersi, S.K. Akiyama, Q.X.A. Sang, L. Howard, M. Pineiro-Sanchez, H. Nakahara, Y. Yeh, and W.-T. Chen (1997) Collagen induces 1 integrin docking of a membrane-bound gelatinase, seprase, at plasma membrane sites of tumor cell invasion. Mol. Biol. Cell (suppl.), 8, 75a.

28. Q.X.A. Sang, Y.E. Shi, and H. Li (1998) Biochemical characterization of human tissue inhibitor of metalloproteinase-4. Keystone Symposium on Angiogenesis and Vascular Remodeling. Steamboat Springs, Colorado. March 28-April 3, 1998.

29. Q.X.A. Sang, H. Li, X. Xu, Y.E. Shi, M.-C. Jia. Tissue inhibitor of metalloproteinase-4 in human breast cancer and endothelial cells. Proeases and Protease Inhibitors in Cancer. A Special Conference of American Association for Cancer Research and ACTA Pathologica Microbiologica Immunologica Scandinavia. Nyborg, Denmark. June 14-18, 1998.

30. Q.X.A. Sang. Complex role of matrilysin and type IV collagenases in angiogenesis. Oral Presentation. In Vascular Endothelium: Mechanisms of Cell Signaling. Edited by J.D. Catravas, A.D. Callow, U.S. Ryan. NATO Science Series. Series A: Life Sciences. Vol. 308, p. 231. IOS Press. 1999. Amsterdam.

31. Q.X.A. Sang, X. Xu, Y.E. Shi, H. Li. Tissue inhibitor of metalloproteinase-4 in human breast cancer and endothelial cells. In Vascular Endothelium: Mechanisms of Cell Signaling. Edited by J.D. Catravas, A.D. Callow, U.S. Ryan. NATO Science Series. Series A: Life Sciences. Vol. 308, p. 270. IOS Press. 1999. Amsterdam.

32. Q.X.A. Sang, M.A. Schwartz, H. Li, L.W.K. Chung, and H.E. Zhau. Targeting matrix metalloproteinases in human prostate cancer. Inhibition of Matrix Metalloproteinases: Therapeutic Applications. A New York Academy of Sciences Conference. Tampa, Florida. October 21-24, 1998.

33. Q.X.A. Sang, M.A. Schwartz, H. Li, L.W.K. Chung, and H.E. Zhau. Inhibition of prostate cancer matrix metalloproteinases. Metalloproteases: Chemistry, Biology and Medicine. A Keystone Symposium on Molecular & Cellular Biology, Tamarron, Colorado, Feb. 25-March 3, 1999. Organizers: H. Nagase, J.F. Woessner, Jr., J.S. Bond.

34. M.-C. Jia, M.A. Schwartz, V.L.D. Badisa, M.A. Ghaffari, Y.-L. Luo, M.C. Jaye, H.K. Kleinman, Q.A. Sang. Matrixins and metalloproteinase inhibitiors in human endothelial cell growth, differentiation, and angiogenesis. 5th Biannual International Conference on Angiogenesis: From the Molecular to Integrative Pharmacology. Crete, Greece. July 1-7,1999.

35. M.-C. Jia, M.A. Schwartz, V.L.D. Badisa, M.A. Ghaffari, Y.-L. Luo, M.C. Jaye, H.K. Kleinman, Q.A. Sang. Inhibition of human endothelial cell growth, differentiation, and angiogenesis by novel synthetic metalloproteinase inhibitors. Gordon Research conference on Matrix Metalloproteinases. New London, New Hampshire. August 8-13,1999.

36. Q.X.A. Sang, M.A. Schwartz, and M.-C. Jia. Targeting angiogenesis and cancer invasion with metalloproteinase inhibitors. 2nd International Conference on Protease Inhibitors. Gainesville, Florida. December 3-6, 1999.

37. H.I. Park, J. Ni, F.E. Gerkema, L. Ding, V.E. Belozerov, and Q.-X. Sang. Expression, activation, and inhibition of a novel matrix metalloproteinase, endometase. An International Symposium "Proteinase Inhibitors and Activators" Strategic Targets for Therapeutic Intervention. University of Oxford, England, UK. April 17-20, 2000.

38. H.I. Park, J. Ni, F.E. Gerkema, L. Ding, V.E. Belozerov, and Q.-X. Sang. Endometase, a Novel Matrixin Derived from Human Endometrial Tumor and Endothelium. NATO Conference on Vascular Endothelium: Source and Target of Inflammatory Mediators. NATO Advanced Study Institute. Crete, Greece. June 24-July 3, 2000.

39. Hurst DR, Li H, Badisa VLD, Shi YE, Sang QX. Characterization of a polyclonal antibody specifically against tissue inhibitor of metalloproteinases 4 in human breast cancer. ECM 2000: International Conference on the Biology and Pathology of the Extracellular Matrix. St. Louis, Missouri. October 12-15, 2000.

40. H.I. Park, J. Ni, F.E. Gerkema, L. Ding, V.E. Belozerov, and Q.-X. Sang. Biochemical characterization of human endometase (MMP-26) from endometrial tumor. ECM 2000: International Conference on the Biology and Pathology of the Extracellular Matrix. St. Louis, Missouri. October 12-15, 2000.

41. H.I. Park, M.A. Schwartz, and Q.-X. Sang. Structure-function relationship of human endometase active site. 4th Biannual Structural Biology Symposium. Computational Structural Biology: From Simulation to Experiment & Back. Florida State University, Tallahassee, Florida. January 18-21, 2001.

42. Q.-X.A. Sang, H.I. Park, J. Ni, D. Liu, F.E. Gerkema, and Y.-G. Zhao. Discovery of a novel matrix metalloproteinase (MMP-26), endometase, from human endometrial and prostate cancers. 5th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association," Molecular Biology and New Therapeutic Strategies: Cancer Research in the 21st Century". Poster B1. Maui, Hawaii. February 12-16, 2001.

43. Q.-X.A. Sang, J. Ni, F.E. Gerkema, D. Liu, V.E. Belozerov, and H.I. Park (2001). Biochemical properties of human endometase/MMP-26, a unique new metalloproteinase specifically expressed in uterus, placenta, and cancer cells. American Society for Biochemistry and Molecular Biology Annual Meeting held jointly with Experimental Biology. Orlando, Florida. March 30-April 6, 2001. FASEB J. 15 (4), page A189.

44. Y.-G.Zhao, P. Wei, L. Zhuang, S. Ruben, and Q.-X.A. Sang (2001). Human disintegrin and metalloproteinase ADAM19 (hADAM19): Cloning, expression and enzymatic characterization. American Society for Biochemistry and Molecular Biology Annual Meeting held jointly with Experimental Biology. Orlando, Florida. March 30-April 6, 2001. FASEB J. 15 (4), page A189

45. D.R.Hurst, M.A. Schwartz, M.A. Ghaffari, H. Tschesche, and Q.-X.A. Sang (2001). New thiol metalloproteinase inhibitors: an examination of the catalytic domain of membrane-type 1 matrix metalloproteinase in human breast cancer. American Society for Biochemistry and Molecular Biology Annual Meeting held jointly with Experimental Biology. Orlando, Florida. March 30-April 6, 2001. FASEB J. 15 (4), page A539

46. Y.-G. Zhao, P.Wei, L. Zhuang, D.R. Hurst, S. Ruben and Q.-X. Sang. Immunological and enzymatic characterization of human disintegrin and metalloproteinase 19 (hADAM 19)/Meltrin beta. Cold Spring Harbor Laboratory Meeting on Proteolysis and Biological Control. Cold Spring Harbor, NY. May 2-6, 2001.

47. H.I. Park, J. Ni, F.E. Gerkema, F.-L. Yu, Y.-G. Zhao, V.E. Belozerov, D. Liu, M.A. Schwartz, L. J. Windsor, and Q.-X. A. Sang. Discovery and characterization of human endometase/MMP-26, a unique new metalloproteinase specifically expressed in uterus, placenta, and cancer Cells. Gordon Research Conference on Matrix Metalloproteinase. Italy, May 13-18, 2001.

48. Y.-G. Zhao, P. Wei, L. Zhuang, L.D. Covassin, D.R. Hurst, S. Ruben, and Q.-X. Sang. Human disintegrin and metalloproteinase 19, expression, characterization, and potential functions. International Congress on Membrane-bound Proteolytic Enzymes and Cancer". Palermo, Italy. May 19-21, 2001.

49. H.I. Park, J. Ni, F.E. Gerkema, F. Yu, Y.-G. Zhao, D. Liu, M.A. Schwartz, L.J. Windsor, and Q.-X. Sang. Discovery of a novel angiogenesis and cancer-associated human matrix metalloproteinase MMP-26/endometase. 6th Biannual International Conference on Angiogenesis: Basic Science and Clinical Developments. Crete, Greece. June 26-July 1, 2001.

50. Y.-G. Zhao, P. Wei, L. Zhuang, L.D. Covassin, D.R. Hurst, S. Ruben, and Q.-X. Sang. Identification of human adamalysin-19 (disintegrin and metalloproteinase 19) and its putative functions in cardiovascular system and cancer. 6th Biannual International Conference on Angiogenesis: Basic Science and Clinical Developments. Crete, Greece. June 26-July 1, 2001.

51. H.I. Park, M.A. Schwartz, and Q.-X. Sang. Structure-function relationship of the active site in human endometase (MMP-26) from endometrial tumor. American Association for Cancer Research Workshop "Pathology of Cancer", the Edward A. Smuckler Memorial Workshop. Keystone, Colorado. July 15-22, 2001.

52. H.I. Park, Y.-G. Zhao, T.-B. Kang, E. Filenova, M.A. Schwartz, J. Ni, F. Yu, L.J. Windsor, and Q.-X. Sang. Human matrix metalloproteinase-26 in cancer: substrate specificity, inhibition profile, and potential functions. "Imaging in 2020 Conference" organized by the California Institute of Technology and National Cancer Institute. Jackson Hole, Wyoming. September 29, 2001-October 4, 2001.

53. D.R. Hurst, M.A. Schwartz, Y.-H. Jin, M.A. Ghaffari, H. Tschesche, and Q.-X. Sang. New mercaptoalkylsulfide inhibitors targeting membrane-type 1 matrix metalloproteinase. 2nd General Meeting of the International Proteolysis Society associated with the International Conference on Protease Inhibitors. Freising, Germany. October 31-November 4, 2001.

54. H.I. Park, J. Ni, F.-L. Yu, Y.-G. Zhao, E. Filenova, M.A. Schwartz, L.J. Windsor, and Q.X. Sang. Human endometase/MMP-26 may be a novel marker for carcinoma diagnosis and a new target for cancer treatment. 2nd General Meeting of the International Proteolysis Society associated with the International Conference on Protease Inhibitors. Freising, Germany. October 31-November 4, 2001.

55. Y.-G. Zhao, P. Wei, L. Zhuang, D.R. Hurst, L.D. Covassin, S. Ruben, and Q.-X. Sang. Human membrane adamalysin-19 expression, enzymatic activity, and neutralizing antibodies. 2nd General Meeting of the International Proteolysis Society associated with the International Conference on Protease Inhibitors. Freising, Germany. October 31-November 4, 2001.

56. H.I. Park, Y.-G. Zhao, T.-B. Kang, E. Filenova, F.-L. Yu, M.A. Schwartz, and Q.-X.A. Sang.  Endometase/Matrilysin-2 in Human Endometrial, Breast, and Prostate Cancers. Molecular Imaging in Cancer: Linking Biology, Function, and Clinical Applications In Vivo. An American Association for Cancer Research (AACR) Special Conference in Cancer Research. Lake Buena Vista, FL. January 23-27, 2002.

57. C.A. Monroe, Y.-H. Jin, M. Ghaffari, H.I. Park, M.A. Schwartz, and Q.-X. Sang.  The biochemical characterization of human endometase. 2001-2002 Summer Undergraduate Research Program, Pfizer Global Research & Development. Groton Laboratories, Groton Connecticut, USA.  April 5, 2002.

58. T. Kang, Y.-G. Zhao, D. Pei, J.F. Sucic, and Q.-X. Sang. Molecular Mechanism of Intracellular Activation of Human Adamalysin 19 (hADAM19 or Meltrin Beta) by a Proprotein Convertase Furin.  Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors.  Colby-Sawyer College, New London, New Hampshire.  July 7-12, 2002

59.  Y.-G. Zhao, H.I. Park, M.A. Schwartz, M.-C. Jia, and Q.-X. Sang.  A New Metalloproteinase in Cancer Progression and Angiogenesis.  Pathobiology of Cancer Workshop.  American Association for Cancer Research. Keystone, Colorado.  July 14-21, 2002.

60.  D.R. Hurst, M.A. Schwartz, Y.-H. Jin, M.A. Ghaffari, H. Tschesche, and Q.-X. A. Sang.  Targeting membrane type 1-matrix metalloproteinase with mercaptoalkylsulfide inhibitors.  Era of Hope, Department of Defense Breast Cancer Research Program Meeting.  Proceedings vol. II, p27-4. Orlando, Florida. September 25-28, 2002.

 

61.  Y.-G. Zhao, A.-Z. Xiao, T. Kang, L.W.K. Chung, M.G. Swanson, H.E. Zhau, J. Kurhanewicz, and Q.-X.A. Sang.  Putative Role of Endometase/Matrilysin-2 in Prostate Cancer Cell Invasion. An American Association for Cancer Research Special Conference on Proteases, Extracellular Matrix, and Cancer. Hilton Head Island, South Carolina. October 9-13, 2002.

 

62.  H.I. Park, Y.-H. Jin, C.A. Monroe, S.C. Monroe, M.A. Schwartz, and Q.-X. A. Sang. Inhibition Characteristics of a New Matrix Metalloproteinase MMP-26: Selectivity in Nonprime Site.  An American Association for Cancer Research Special Conference on Proteases, Extracellular Matrix, and Cancer. Hilton Head Island, South Carolina. October 9-13, 2002.

 

63.  D.R. Hurst, M.A. Schwartz, Y. Jin, H. Tschesche, and Q.-X.A. Sang. Exploring the Active Site of Membrane Type 1-Matrix Metalloproteinase with New Mercaptosulfide Inhibitors. 54th Southeast Regional Meeting of the American Chemical Society. Charleston, SC, November 14, 2002.

 

64.  T. Kang, H. Tschesche, and Q.-X. A. Sang. Regulation of Enzyme Stability by the Cysteine Residues of the Residual Cysteine-rich Domain of the C-terminal Fragment Retained by the Autocatalytic Processing at Glu586-Ser587 of Human Adamalysin 19/ADAM19. Gordon Research Conference on Matrix Metalloproteinase.  Conference Chairpersons:  Christopher M. Overall and Zena Werb.  Big Sky, Montana.  August 17-22, 2003.

 

65.  Y.-G. Zhao, A.-Z. Xiao, H.I. Park, R.G. Newcomer, M. Yan, Y.-G. Man, S.C. Heffelfinger, and Q.-X. Sang (2003) Endometase in human breast carcinomas, selective activation of progelatinase B and inhibition by tissue inhibitors of metalloproteinases-2 and -4. 26th Annual San Antonio Breast Cancer Symposium. Dec. 3-6, 2003. Poster no. 271. Special Issue. Breast Cancer Res. Treat. 82, Suppl. 1, S64.

 

66.  Y.-G. Man, R. Mattu, R. Zhang, M. Yousefi, Q.X.A. Sang, and T. Shen (2003) A subset of normal and hyperplastic appearing mammary ductal cells display invasive features. 26th Annual San Antonio Breast Cancer Symposium. Dec. 3-6, 2003. Poster no. 573. Special Issue. Breast Cancer Res. Treat. 82, Suppl. 1, S141.

 

67.  Y.-G. Man, R. Zhang, R. Mattu, T. Shen, and Q.X.A. Sang (2003) A subset of mammary epithelial cells overlying focally disrupted myoepithelial cell layers shows an unusual immunostaining pattern for proliferation-related proteins. 26th Annual San Antonio Breast Cancer Symposium. Dec. 3-6, 2003. Poster no. 670. Special Issue. Breast Cancer Res. Treat. 82, Suppl. 1, S163.

 

68.  Q.-X. Sang, H.I. Park, Y. Jin, Y. Zhao, A. Xiao, D.R. Hurst, C.A. Monroe, S. Lee, R.G. Newcomer, M.A. Schwartz (2004) Inhibition of endometase/matrilysin-2 by tissue inhibitors of metalloproteinases and new synthetic mercaptosulfide inhibitiors and implications in human prostate and breast cancers.  Proc. Am. Assoc. Cancer Res. 45, Abst. No. 1835, March 29, 2004.

 

69.  Y.-G. Man, T. Shen, Y. Zhao, and Q.-X. Sang (2004) Focal prostate basal cell layer disruptions and leukocyte infiltration are correlated events: implications for tumor invasion. Proc. Am. Assoc. Cancer Res. 45, Abst. No. 1775, March 29, 2004.

 

70.  Y.-G. Man, T. Shen, Y. Zhao, and Q.-X. Sang (2004) Morphologically comparable prostate acini and ducts with and without a focal basal cell layer disruption have a different cell proliferation rate: implications for tumor invasion. FASEB J. 18, p. A1183. Abst. No. 786.11. April 21, 2004.

 

71.  Hurst DR, Schwartz MA, Jin Y, Ghaffari MA, and Sang QXA (2004) Inhibition Characteristics of Membrane Type 1-Matrix Metalloproteinase with Novel Mercaptosulfide Inhibitors. “Pathobiology of Cancer Workshop” organized by NCI and AACR. Snowmass Village, CO, July 18-25, 2004.

 

72.  Y.-G. Man, T. Shen, Y.-G. Zhao, and Q.-X. A. Sang (2004) Prostate basal cell layer disruptions and leukocyte infiltration (Endometase/matrilysin-2 in invasion and inflammation). 10th Prouts Neck Meeting on Prostate Cancer. Late Stage Prostate Cancer: a Multidisciplinary Approach. pp. 60. Nov. 4-7, 2004. Black Point Inn, Prouts Neck, Maine. Organized by the National Cancer Institute and University of Pittsburgh Cancer Institute.

 

73.  S. Lee and Q.-X. Sang (2004) The role of calcium ions in the structure and function of matrixmetalloproteinase-26. 56th Southeast Regional Meeting of the American Chemical Society. Research Triangle Park, NC, November 11, 2004

 

74.  Y.-G. Man and Q.-X. A. Sang (2004) Human prostate basal cell layer disruptions and leukocyte infiltration. American Association for Cancer Research Special Conference on Basic, Translational, and Clinical Advances in Prostate Cancer. Poster A5. Nov. 17-21, 2004. Bonita Springs, Florida.

 

75.  Y. Zhao, A. Xiao, Y. Jin, M.A. Schwartz, and Q.-X. Sang (2004) Inhibition of MDA-MB-435 cell invasion by a synthetic matrix metalloproteinase inhibitor. The American Society for Cell Biology 44th Annual Meeting, December 4-8, 2004 Washington DC. Page 179, abstract # 2344, Poster # B351.

 

76.  Q.-X. Sang, Y.-G. Zhao, and Y.-G. Man (2005) Mechanism of human prostate cancer invasion: Basement membrane degradation and basal cell layer disruption. Proceedings of American Association for Cancer Research 46, page 1106, Poster #4689. April 16-20, 2005. Anaheim, California.

 

77.  Y.-G. Man, P.E. Berg, Q.-X. Sang (2005) Differential expression of tumor invasion related proteins in cells overlying focally disrupted myoepithelial cell layers and adjacent cells within the same duct. Era of Hope: Proceedings of Department of Defense Breast Cancer Research Program Meeting Poster P10-5, p75. June 8-11, 2005. Philadelphia, Pennsylvania.

 

78.  Y. Zhao, A. Xiao, and Q.-X. Sang (2005) The novel three dimensional cell culture system for human breast cancer: cancer invasion and cell-cell interaction. Era of Hope: Proceedings of Department of Defense Breast Cancer Research Program Meeting Poster P59-24, p417. June 8-11, 2005. Philadelphia, Pennsylvania.

 

79.  M.E. Muroski, D. R. Hurst, Y. Jin, M.A. Schwartz, and Q.-X. Sang (2005) Potency and Selectivity of Selected Metalloproteinase Inhibitors. 37th Annual Southeast Regional American Chemical Society Undergraduate Research Conference hosted by Mississippi State University, March 31-April 1st, 2005. Poster no. 1. Poster book p. 22.

 

80.  M.E. Muroski, D.R. Hurst, Y. Jin, M.A. Schwartz, and Q.-X. Sang (2005) Potency and Selectivity of Selected Metalloproteinase Inhibitors. 37th Annual Southeast Regional American Chemical Society Undergraduate Research Conference hosted by Mississippi State University, March 31-April 1st, 2005. Oral Presentation no 1. Poster book, p. 4.

 

81.  K.K. Desai, R.G. Newcomer, K.A. Iczkowski, Y.-G. Zhao, M.D. Roycik, and Q.X.A. Sang (2005) Expression levels of tissue inhibitor of metalloproteinases-4 and matrix metalloproteinase-26 correlate with the invasive potential of HGPIN in human prostate tissue. 37th Annual Southeast Regional American Chemical Society Undergraduate Research Conference, Mississippi State University, March 31-April 1, 2005.

 

82.  Y.G. Man and Q.-X. Sang (2005) Myoepithelial cell layer disruption and human breast cancer invasion. Breast Cancer Research. Vol. 7, Suppl. 2, June 2005. Poster P3.06, p. S33. The Third International Symposium on the Molecular Biology of Breast Cancer. Molde, Norway, 22-26 June 2005.

 

83.  Sahab, Z.J., and Sang, Q.-X. (2005) Albumin elimination from human plasma. Abstracts of Papers, 230th American Chemical Society National Meeting, Washington, DC, U.S., Aug. 28-Sept. 1, 2005, ANYL-150.  CODEN: 69HFCL AN 2005:736142.

 

84.  Sahab, Z.J., Suh, Y., and Sang, Q.-X. (2005) Pre-fractionation of proteins from crude biological samples prior to 2-D gel electrophoresis. Abstracts of Papers, 230th American Chemical Society National Meeting, Washington, DC, United States, Aug. 28-Sept. 1, 2005 , ANYL-151.  CODEN: 69HFCL AN 2005:736143.

 

85.  Sahab, Z.J., Suh, Y., and Sang, Q.-X. (2005) Narrow isoelectric-point based pre-fractionation of proteins from crude biological samples.  Abstracts of Papers, 230th American Chemical Society National Meeting, Washington, DC, U.S., Aug. 28-Sept. 1, 2005, ANYL-246.  CODEN: 69HFCL AN 2005:736238.

 

86.  D.R. Hurst, M.A. Schwartz,Y. Jin, M.A. Ghaffari, P. Kozarekar, J. Cao, Q.-X. Sang (2005) Inhibition of enzyme activity and cell-mediated substrate cleavage of membrane type 1-matrix metalloproteinase by newly developed mercaptosulfide inhibitors. Matrix Metalloproteinases Gordon Research Conference, Big Sky, Montana. Aug. 28-Sept. 2, 2005. Poster number 118.

 

87.  Y. Jin, Q. Cao, Q.-X. Sang and M.A. Schwartz (2006) Zinc Metalloproteinase Inhibitors with 1,2-Dihydroxy benzene and 3-Hydroxy-4-pyrone as Zinc Binding Groups. 231st American Chemical Society National Meeting & Exposition, March 26-30, 2006, Atlanta, Georgia.

 

88.  S. Lee and Q.-X. Sang (2006) Effects of human endometase/matrilysin-2/MMP-26 on the invasive potential and protein expression patterns of a human breast cancer cell line MDA-MB-231. American Chemical Society (ACS) Paper #36620 - 58th Southeast Regional Meeting. November 1-4, 2006. Augusta, Georgia.

 

89.  Q.-X. Sang, S. Lee, H.I. Park, Y.-G. Zhao, Y. Jin, and M.A. Schwartz (2007) Unique Structure and Function of Endometase/Matrilysin-2, a Putative Cancer Biomarker. Invited Plenary Talk. American Chemical Society, Florida Section Meeting, Orlando, Florida. May 11, 2007. Talk number 115.

 

90.  R.G. Newcomer, M.D. Moussallem, T.C. S. Keller, J.B. Schlenoff, and Q.-X. Sang.  Divergent Human Vascular Smooth Muscle Cell Response to Polyelectrolyte Multilayer Bio-Interfaces. Invited Talk. American Chemical Society, Florida Section Meeting, Orlando, Florida. May 11, 2007.  Talk number 114.

 

91.  S.M. Semaan, Z.J. Sahab, Y. Suh, and Q.-X. Sang. Extraction of Basic Proteins using Batch Anion Exchange Chromatography Prior to Profiling and Identification. American Chemical Society, Florida Section Meeting, Orlando, Florida. May 10-12, 2007.  Poster number 224.